ABSTRACT
Alzheimer's disease (AD) is a neurodegenerative brain disease, and it is challenging to mine features that distinguish AD and healthy control (HC) from multiple datasets. Brain network modeling technology in AD using single-modal images often lacks supplementary information regarding multi-source resolution and has poor spatiotemporal sensitivity. In this study, we proposed a novel multi-modal LassoNet framework with a neural network for AD-related feature detection and classification. Specifically, data including two modalities of resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion tensor imaging (DTI) were adopted for predicting pathological brain areas related to AD. The results of 10 repeated experiments and validation experiments in three groups prove that our proposed framework outperforms well in classification performance, generalization, and reproducibility. Also, we found discriminative brain regions, such as Hippocampus, Frontal_Inf_Orb_L, Parietal_Sup_L, Putamen_L, Fusiform_R, etc. These discoveries provide a novel method for AD research, and the experimental study demonstrates that the framework will further improve our understanding of the mechanisms underlying the development of AD.